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Image Search Results
Journal: International Journal of Molecular Sciences
Article Title: Physical Activity Rewires the Human Brain against Neurodegeneration
doi: 10.3390/ijms23116223
Figure Lengend Snippet: Overall study design. ( A ) We searched GEO and BaseSpace Correlation Engine (BSCE) databases for brain transcriptomic studies from subjects who engaged in different levels of physical activity and individuals with neurodegenerative diseases, including Alzheimer’s (AD), Parkinson’s (PD), Huntington’s diseases (HD), and frontotemporal dementia (FTD). Studies that met our inclusion/exclusion criteria were analyzed further. ( B ) Dataset GSE110298 containing brain transcriptomic data from aged cognitively intact individuals who engaged in different physical activity levels were analyzed by SWIM software to identify switch genes. Pathway and transcription factor analyses were performed in NetworkAnalyst. Gene ontology associations of switch genes were retrieved from HUGO database. Transcriptomic hippocampal data from subjects engaged in high and moderate physical activity were compared to those engaged in low physical activity using the meta-analysis and correlation engine tool in BSCE. Using this tool, we compared the transcriptome of physically active subjects with patients with neurodegenerative diseases to identify shared and unique pathways affected by physical activity.
Article Snippet: We searched the
Techniques: Activity Assay, Software